Genome-wide DNA methylation analysis reveals several loci important for blood lipid levels
نویسندگان
چکیده
Liliane Pfeiffer, Simone Wahl, Luke C. Pilling, Eva Reischl, Katharina Schramm, Anja Kretschmer, Sonja Zeilinger, Jerzy Adamski, Norman Klopp, Thomas Illig, Michael Roden, Dena Hernandez, Andrew B. Singleton, Stefania Bandinelli, Harald Grallert, Christian Gieger, Christian Herder, Christa Meisinger, Florian Kronenberg, Holger Prokisch, David Melzer, Annette Peters, Luigi Ferrucci, Melanie Waldenberger *
منابع مشابه
Predicting CpG Islands and DNA Methlation in the Cow Genome Using DNA Microarray Meta-Analysis and Genome Wide Scanning
DNA methylation is a type of epigenetic changes that directly affects DNA. In mammals, DNA methylation is essential for fetal development and stem cell differentiation and this phenomenon essentially occurs within the CpG islands. In this study, two methods were used to study the DNA methylation profile of cow genome. In the first method, the DNA methylation profile of the differentially expres...
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BACKGROUND Genome-wide association studies have identified loci influencing circulating lipid concentrations in humans; further information on novel contributing genes, pathways, and biology may be gained through studies of epigenetic modifications. METHODS AND RESULTS To identify epigenetic changes associated with lipid concentrations, we assayed genome-wide DNA methylation at cytosine-guani...
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BACKGROUND Epigenetic mechanisms might be involved in the regulation of interindividual lipid level variability and thus may contribute to the cardiovascular risk profile. The aim of this study was to investigate the association between genome-wide DNA methylation and blood lipid levels high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and total cholester...
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DNA methylation is an important component of epigenetic modifications that influences the transcriptional machinery and is aberrant in many human diseases. Several methods have been developed to map DNA methylation for either limited regions or genome-wide. In particular, antibodies specific for methylated CpG have been successfully applied in genome-wide studies. However, despite the relevance...
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Background Genomic imprinting is a heritable and developmentally essential phenomenon by which gene expression occurs in an allele-specific manner1. While the imprinted alleles are primarily silenced by DNA methylation, it remains largely unknown how methylation is targeted to imprinting control region (ICR), also called differentially methylated region (DMR), and maintained. Here we show that ...
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